Eosinophilic Gastroenteritis

An Update

Alfredo J Lucendo; Angel Arias

Disclosures

Expert Rev Gastroenterol Hepatol. 2012;6(5):591-601. 

In This Article

Expert Commentary

EGIDs constitutes an increasingly common heterogeneous group of intestinal diseases with assorted clinical manifestations depending on the organ involved and the extent of inflammation into the digestive walls. As such, they should be considered as a diagnostic possibility for patients with common gastrointestinal symptoms. The study of these complex disorders, which share an eosinophil-rich infiltration as a common hallmark, has focused on the similarities they usually share, mainly their association with allergic manifestations, especially Th2-driven bronchial disorders, and a common response to corticosteroids. Both the symptoms and molecular basis of EoE, the most widely studied form of EGID, has been well defined, but the small number of diagnosed EGE cases (due to epidemiological reasons) has limited the primary knowledge of this disease, which manifests with extremely heterogeneous symptoms. Researchers, through systematic registries of whole cases that exhaustively include clinical and immunological characteristics of patients, type, response to therapy, evolution of the disease and even molecular data, should now have access to enough information to broaden our knowledge about EGE. Theses registries should constitute the pillars for subsequent multicenter studies, which should seek to delimit the etiology, pathogenesis, and best therapeutic alternatives in order to prevent and even modify the outcomes of these relevant disorders.

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