The Changing Landscape of Therapeutic Strategies for Recurrent Ovarian Cancer

Klaus H Baumann; Uwe Wagner; Andreas du Bois


Future Oncol. 2012;8(9):1135-1147. 

In This Article

Timing of Therapy in Recurrent Ovarian Cancer

Patients presenting with symptoms caused by recurrent ovarian cancer will receive further diagnostic procedures and eventually appropriate treatment recommendation. In the absence of any signs and disease symptoms, the scope of diagnostic procedures and the consequences are still a matter of debate. The initiation of therapy for relapsed ovarian cancer based solely on the rise of CA-125 in the absence of any symptoms or evaluable or measurable tumor burden by imaging techniques, might not result in a survival benefit.[14] PET–computed tomgraphy might lead to earlier detection of relapsing ovarian cancer and influence surgical and systemic treatment decision.[15,16] The impact of this sophisticated strategy on survival of women with recurrent ovarian cancer has not yet been elucidated.

Follow-up, initiation, execution and tailoring of treatment in case of recurrence of ovarian cancer have to take into account evidence-based guidelines and the individual situation of women.