Giant Cell Tumor of the Larynx

Thu Le, MD; Kevin Young, MD; Bernard Chow, MD


Appl Radiol. 2012;41:29a-29d. 

In This Article

Histologic Findings

The smear and cell block from the right neck mass aspiration show abundant giant cells admised with spindle cells (Figure 3). The nuclei of the giant cells and the spindle cell are similar and show mild irregular nuclear contours and prominent nuclei. Occasional mitotic figures are identified. Immunoperoxidase stains are performed with the following results: negative for Keratin AE-1-AE3, Keratin CAM 5.2, Keratin 8, Thyroglobulin, TTF1, Calcitonin, Desmin, and positive for CD 68. The positive CD 68 staining may be seen in the giant cell tumor, or osteosarcoma. There is no bone or osteoid formation noted in this biopsy to support the diagnosis of osteosarcoma.

Figure 3.

(A and B) Low and high-power photomicrograph, H-E stain, show both multinucleated giant cells (arrows) and intervening mononuclear cells.

The pathologic examination of the surgical specimen from neck dissection shows numerous multinucleated osteoclast-like giant cells within cellular and vascular stroma containing plump, oval mononuclear cells with nuclei similar to giant cells (Figure 3); expansile and infiltrative growth; frequent mitotic figures; secondary cystic degeneration, reactive bone formation; no cytologic atypia or pleomorphism.The overall features are most consistent with giant cell tumor of the larynx.