Giant Cell Tumor of the Larynx

Thu Le, MD; Kevin Young, MD; Bernard Chow, MD


Appl Radiol. 2012;41:29a-29d. 

In This Article

Imaging Findings

Computed tomography (CT) of the neck with intravenous iodinated contrast showed a 5 × 4 × 4-cm solid, round, soft-tissue mass with homogenous enhancement centering within the right thyroid cartilage. The right thyroid cartilaginous tissue is replaced by destructive, expansile tumor (Figure 1). The mass is extending into the inferior aspect of the epiglottis, soft tissue of the larynx and into right endolaryngeal space (Figure 2). The lesion appears to be well defined. There is no evidence of perilesional fat stranding. There is no evidence of cervical lymphadenophathy. A CT of the chest showed no evidence of primary neoplasm or distant metastatic disease.

Figure 1.

Axial CT images (A and B) through the neck show an expansile, well-defined, soft-tissue mass centered within thyroid cartilage with destruction and replacement of cartilaginous tissues. There is no perilesional fat stranding. The lesion expands into the right laryangeal space and displaces the strap muscle anteriorly.

Figure 2.

Coronal CT reconstruction images (A and B) of the neck show tumor expansion into inferior aspect of the epiglottis and into the right endolaryngeal space, with obliteration of the right vocal cord and narrowing of the airway.

The patient underwent right-neck fine needle biopsy and aspiration with the cytopathology report of a giant cell tumor of the larynx. He subsequently had right vertical partial laryngectomy and laryngoplasty. Pathologic analysis of the surgical specimen confirms the diagnosis of a giant cell tumor of the larynx with regional lymphovascular invasion. No adjuvant chemotherapy or radiotherapy was provided. Postoperative follow-up for 4 months showed no evidence of recurrence or complication.