Impact of Lifestyle Factors on Prognosis Among Breast Cancer Survivors in the USA

Rachel E Ellsworth; Allyson L Valente; Craig D Shriver; Barry Bittman; Darrell L Ellsworth


Expert Rev Pharmacoeconomics Outcomes Res. 2012;12(4):451-464. 

In This Article

Obesity & Breast Cancer Prognosis

Nearly 36% of adult women in the USA are now obese (BMI >30 kg/m2),[9] and are at increased risk for a number of health conditions such as diabetes, cardiovascular disease and various forms of cancer.[10] Obesity is associated with metastasis recurrence, a shorter disease-free interval and overall survival, and a greater likelihood of treatment failure in breast cancer patients,[11,12] which may be influenced by hormone receptor status and disease stage at diagnosis. Similarly, weight gain after diagnosis is common among women with breast cancer, and is associated with increased mortality and disease recurrence.[13] Each 5-kg gain in weight is associated with a 13% increase in breast cancer mortality.[14] Factors associated with postdiagnosis weight gain include changes in metabolism and physical activity, menopausal and lymph node status, and the duration, intensity and composition of treatment.[15–17] As 41% of adults in the USA are predicted to be obese by 2015,[18] improved understanding of the relationships between obesity, lifestyle factors and prognosis is essential to developing effective strategies to improve breast cancer survival.