For the immediate future, the diagnosis of MS will remain dependent on the clinical examination, MRI findings, laboratory results and electrophysiological data.
MS will remain a clinical diagnosis heavily dependent on prudent interpretation of clinical, MRI, laboratory and electrophysiological data for the foreseeable future. In that sense, the disorder is like many other neurological conditions. It is quite unlikely that a specific biomarker will become available that will permit the diagnosis of MS with any degree of sensitivity or specificity. A better understanding of the pathogenesis of the disorder, however, may alter that prediction. For instance, if a unique infectious etiology is unexpectedly discovered to underlie MS akin to the recent report of a monkey γ-herpes virus causing an animal model of relapsing and remitting demyelinating disease in Japanese macaque monkeys, a single laboratory diagnostic study may be conceivable.
Future Neurology. 2012;7(5):547-555. © 2012 Future Medicine Ltd.