Detecting Multiple Sclerosis Mimics Early

Divya Singhal; Joseph R Berger


Future Neurology. 2012;7(5):547-555. 

In This Article


MS is a common autoimmune condition that is best diagnosed by placing clinical emphasis on dissemination in space and time and remaining receptive to possible alternative diagnoses. Overdiagnosis of MS is common and can result in unnecessary delay of treatment of the underlying condition, as well as potentially grave consequences secondary to the use of newer immunosuppressive disease-modifying medications. In addition, the diagnosis of MS carries a significant burden of psychosocial and financial ramifications for the patient. MS remains a clinical diagnosis. The careful interpretation of clinical, laboratory, neurophysiological and MRI data are important in comfortably establishing the diagnosis. Physicians should be mindful that MS may coexist with other disorders including disorders that may mimic the condition. Prudent utilization of an expanded battery of testing in select cases can have a rewarding impact with accurate diagnosis in a timely fashion and improved treatment, patient satisfaction and quality.