Dapsone 5% Gel: A New Option in Topical Therapy for Acne

Jerry Tan, MD, FRCPC

Disclosures

Skin Therapy Letter. 2012;17(8):1-3. 

In This Article

What Is It?

Dapsone, a synthetic sulfone with an amino moiety linking two sulfone rings (4,4'-diaminodiphenyl sulfone; molecular weight 248.30), has had medical applications for more than 7 decades for treating various medical conditions including dermatitis herpetiformis, leprosy, and malaria. It has been used in the past for severe recalcitrant acne in doses ranging from 25–50 mg/day.

The primary metabolites of dapsone are N-acetyl dapsone and dapsone hydroxylamine. The most important adverse events of dapsone result from the hydroxylamine metabolite. This compound increases oxidative stress on erythrocytes with resultant potential for dose-dependent hemolysis and methemoglobinemia. Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency are more susceptible, as the absence of functional G6PD increases the risk of hemolysis and denaturation of hemoglobin.

It was hypothesized that a topical formulation of dapsone may be appropriate for treating acne vulgaris while minimizing systemic exposure and hematologic risk. Accordingly, a topical gel formulation of dapsone 5% was developed by Atrix Laboratories almost a decade ago for the treatment of acne vulgaris. While this product was approved by Health Canada in 2006, it has only recently been marketed in Canada.

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