Genetics of Renal Cell Carcinoma
Kidney cancer is not a single disease but is composed of a number of different types of cancer that occur in the kidney, each caused by a different gene with a different histology (Linehan, Srinivasan, & Schmidt, 2010). There are several known kidney cancer genes: von Hipppel-Lindau (VHL), met proto-oncogene (hepatocyte growth factor receptor) (MET), folliculin (FLCN), Treacher Collins syndrome 1 (TSC1), Treacher Collins syndrome 2 (TSC2), fumarate hydratase (FH), succinate dehydrogenase (SDH), and protein polybromo- 1 (PB1) also known as BRG1-associated factor 180 (BAF180) (PBRM1) (see Table 2) (Varela et al., 2011).
Urol Nurs. 2012;32(4):182-190. © 2012 Society of Urologic Nurses and Associates