Diagnosis and Treatment of Pemphigus

Daisuke Tsuruta; Norito Ishii; Takashi Hashimoto


Immunotherapy. 2012;4(7):735-745. 

In This Article

Future Perspective

Anti-TNF-α inhibitors are now being used in the treatment of pemphigus. An anti-TNF-α chimeric monoclonal antibody, infliximab and a fusion protein of the TNF-α receptor and IgG, etanercept, were successfully used to treat pemphigus.[94,95] Several cholinergic agonists, a Dsg3 peptide and a p38 mitogen-activated protein kinase inhibitor have also been used.[96]

So far, the etiologic factor for the initial production of autoantibodies in pemphigus remains unclear. After elucidation of these events, targeted therapies can be developed for the treatment of pemphigus.


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