Immunoadsorption Therapy in Patients With Multiple Sclerosis With Steroid-Refractory Optical Neuritis

Michael J Koziolek; Desiree Tampe; Matthias Bühr; Hassan Dihazi; Klaus Jung; Dirk Fitzner; Reinhard Klinge; Gerhard A Müller; Bernd Kitze


J Neuroinflammation. 2012;9(80) 

In This Article


Our clinical results show a high clinical efficacy of tryptophan-IA comparable to PE in the treatment of MS relapses refractory to corticosteroids. Furthermore, our experimental data suggest several possible effects on MS pathogenesis: not only removal of immunoglobulins and complement from plasma, but also reduced levels of circulating autoantigens and regulatory proteins. We suggest that more prospective studies are needed to confirm and extend our results, to give new insights into this treatment approach, to optimize therapeutic IA protocols and, lastly, to investigate further therapeutic principles, for example, T-cell reactivity to MBP before and after IA.


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