Unusual Manifestations of Acute Q Fever

Autoimmune Hemolytic Anemia and Tubulointerstitial Nephritis

Serdal Korkmaz; Nazif Elaldi; Mansur Kayatas; Mehmet Sencan; Esin Yildiz


Ann Clin Microbiol Antimicrob. 2012;11(14) 

In This Article


Q fever is a worldwide zoonosis caused by Coxiella burnetii, a strict intracellular bacterium. Human infection results mainly from infected aerosols generated by farm animals when they give birth or abort. The disease is classified into acute and chronic forms. Chronic form is generally associated with endocarditis, osteomyelitis, infected vascular aneurysms, or infected intravascular prostheses.[1] Acute Q fever often presents either as a self-limiting flu-like illness, hepatitis, or pneumonia. The most frequent clinical manifestation of acute form is a self-limited febrile illness which is associated with severe headache, muscle ache, arthralgia and cough.[2] Other rare manifestations are seizure and coma, meningoencephalitis, thyroiditis, pericarditis, myocarditis, mesenteric lymphadenopathy, pancreatitis, hemophagocytosis, hemolytic anemia, transient hypoplastic anemia, and epididymoorchitis.[3] Here we present a case of acute Q fever together with Coombs' positive AIHA and tubulointerstitial nephritis treated with chlarithromycin, steroids and hemodialysis.


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