This study confirms the efficacy (and noninferiority) of a 7-day course of ciprofloxacin for the treatment of acute pyelonephritis, even in women with severe infection or bacteremia. Shorter treatment courses are potentially beneficial for the individual and the community. The authors and an editorialist caution against extrapolating from these results to other classes of antimicrobials. Increasing resistance of E. coli to ciprofloxacin in some regions will limit the number of patients who can benefit from short-course treatment.
Journal Watch © 2012 Massachusetts Medical Society