Review Article: Vitamin D and Inflammatory Bowel Disease

Established Concepts and Future Directions

M. Garg; J. S. Lubel; M. P. Sparrow; S. G. Holt; P. R. Gibson

Disclosures

Aliment Pharmacol Ther. 2012;36(4):324-344. 

In This Article

Conclusion

Current understanding points to beneficial effects of vitamin D supplementation in patients with IBD in terms of bone and muscle preservation, reduction in inflammation and potentially reduced risk of cancer in patients with IBD. However, these beneficial effects must be balanced with potential adverse effects in the clinical setting. The precise thresholds of serum 25(OH) vitamin D for beneficial and potentially adverse effects remain poorly defined in the literature. Until further evidence is available, we recommend to aim for a serum 25(OH) vitamin D level of 75 nmol/L. In a condition with a propensity to affect young people and a disproportionate effect on quality of life and productivity, the potential advent of inexpensive supplementary therapies presents an attractive option for ongoing research.

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