Subcutaneous Allergen Immunotherapy for Allergic Disease

Examining Efficacy, Safety and Cost-Effectiveness of Current and Novel Formulations

Linda Cox; Moisés Calderón; Oliver Pfaar


Immunotherapy. 2012;4(6):601-616. 

In This Article

Future Perspective

In the next 5–10 years it is likely that SCIT will involve more modified formulations, such as peptide fragments or modified extracts in conjunction with immune-stimulatory adjuvants. In addition to improved efficacy and safety, these modified extracts/vaccines may allow for shorter courses of treatment (e.g., four to six injections). The short-course treatments may be more 'attractive' to patients who find it difficult to adhere to a 3–5 year SCIT regimen that requires regular office visits or to those who dislike taking daily sublingual tablets or solution. This may result in a much larger percentage of allergic patients subscribing to allergen immunotherapy than the small percentage that currently receives it (~5% of the allergic population).[82]


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