Signaling Pathways Activated by the B-Cell Receptor in Chronic Lymphocytic Leukemia

Maria Teresa Scupoli; Giovanni Pizzolo

Disclosures

Expert Rev Hematol. 2012;5(3):341-348. 

In This Article

PLCγ2 Pathway

Activation of PLCγ2 by SYK, BTK and BLNK results in production of the second messenger, inositol-1,4,5-trisphosphate (IP3), and diacylglycerol (DAG), which lead to the subsequent increase in intracellular Ca2+ concentration and activation of PKC-β, respectively. PKCβ activity leads in turns to the activation of MAPKs, specifically, ERK, JNK and p38 MAPK.[14] PKC-β activity also induces phosphorylation and subsequent degradation of the NF-κB inhibitor (IκB), and thus activating NF-κB, which has important regulatory functions in B-cell activation, maturation and survival.[15] Increased intracellular Ca2+ concentration mediated by IP3 induces activation of nuclear factor of activated T cells (NFAT), a calcium-dependent transcription factor downstream of the calmodulin/calcineurin pathway involved in the development of mature B cells.[16]

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.

processing....