Effect of Pretreatment With Lactobacillus Gasseri OLL2716 on First-Line Helicobacter Pylori Eradication Therapy

Ryuzo Deguchi; Hidemasa Nakaminami; Emiko Rimbara; Norihisa Noguchi; Masanori Sasatsu; Takayoshi Suzuki; Masashi Matsushima; Jun Koike; Muneki Igarashi; Hideki Ozawa; Ryuki Fukuda; Atsushi Takagi

Disclosures

J Gastroenterol Hepatol. 2012;27(5):888-892. 

In This Article

Results

Demographic Background

Demographic characteristics and adverse effects are shown in Table 2. There were no significant differences in demographic features and endoscopic diagnoses. H. pylori was diagnosed by either the UBT or H. pylori culture during endoscopic examination. There were no significant differences between the two groups regarding adverse effects.

H. Pylori Susceptibility to CAM

The status of H. pylori susceptibility to CAM was successively determined in 188 of 229 samples. DNA sequencing of the H. pylori 23S rRNA gene without mutation (wild type) was archived in 137 patients. The 23S rRNA gene with 2142G or A2143G mutation was detected in 51 patients. Mixed infections with both CAM-susceptible and-resistant H. pylori were detected in 13 samples.

H. Pylori Eradication Rates

UBT and stool antigen test results were consistent except in one patient. This discordant case was followed by endoscopic examination, and was revealed to be a false-positive result of the stool antigen test.

Based on ITT analysis, eradication rates in the yogurt-plus-triple and triple-only groups were 82.6 and 69.3%, respectively (P = 0.018) (Table 3). PP analysis also showed that H. pylori eradication rates in the yogurt-plus-triple group (85.6%) were significantly higher than those in the triple-therapy-only group (74.5%) (P = 0.041). Eradication rates of CAM-sensitive H. pylori were high in both groups (Table 4). Eradication of primary CAM-resistant strains tended to be higher in the yogurt-plus-triple group than in the triple-therapy-only group (38.5 vs 28.0%, respectively, P = 0.428). In addition, in mixed infections with both CAM-susceptible and -resistant H. pylori, the eradication rate in the yogurt-plus-triple group was 50% (3/6), however, that in the triple-therapy-only group was 0% (0/4). One patient in the yogurt-plus-triple group and two patients in the triple-therapy-only group were lost to follow up.

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