Coadministration of Probiotics With Antibiotics

Why, When and for How Long?

Lyudmila Boyanova; Ivan Mitov


Expert Rev Anti Infect Ther. 2012;10(4):407-409. 

In This Article


Antibiotic use can lead to dysbiosis.[5] In our study [Boyanova L, Unpublished Data], 4.5% of 67 patients evaluated for Helicobacter pylori exhibited false-positive13C urea breath test results (Richen-Force, Beijing, China) due to non-H. pylori Gram-negative bacteria isolated from gastric biopsies. Additionally, we observed Candida overgrowth in 24.1% of 58 fecal specimens from treated patients sent for Campylobacter diagnostics [Boyanova L, Unpublished Data]. Probiotics reduce the risk of antibiotic-induced super infections. Orally/intravaginally administered Lactobacillus acidophilus, L. rhamnosus GR-1 and Lactobacillus fermentum RC-14 can prevent vulvovaginal candidiasis.[6] Consuming L. rhamnosus GG-containing cheese for 16 weeks reduced the risk of high yeast counts by 75% in elderly people.[7] Probiotic administration is promising alongside antibiotic treatment of bacterial vaginosis. When a single dose of tinidazole (2g) was supplemented with L. rhamnosus GR-1 and Lactobacillus reuteri RC-14 for 4 weeks, the cure rate of bacterial vaginosis increased by >37% compared with the placebo group.[8]


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