Nonalcoholic Fatty Liver Disease and Bariatric Surgery

Sindu Stephen; Ancha Baranova; Zobair M Younossi


Expert Rev Gastroenterol Hepatol. 2012;6(2):163-171. 

In This Article

Five-year View

Similar to other clinical scenarios requiring surgical intervention, there have been efforts to strive for a less invasive technique in bariatric surgery. Although studies of endoscopically placed gastric balloons have been reported, this approach does have several limitations. Two incisionless restrictive surgeries are being investigated. Another procedure is attempting to place a lining in a portion of the small intestine producing malabsorption. As obesity-related comorbidities rise and the age of onset decreases, the guidelines will likely approve bariatric interventions surgery for patients with lower BMIs. More studies of repeat postsurgery biopsies will be performed; these will routinely include profiling of a variety of molecular biomarkers both in the liver and in the serum. One of the key areas for future research in obesity will focus on gut hormones, such as ghrelin and leptin. Future studies will stratify bariatric patients as having 'metabolically benign' and 'metabolically malignant' obesity and determine whether these groups of patients derive similar liver function-related benefits of weight reduction.


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