The Management of Pain in Metastatic Bone Disease

Sorin Buga, MD; Jose E. Sarria, MD


Cancer Control. 2012;19(2):154-166. 

In This Article


The overriding goal in treating cancer pain is to maintain our patients' quality of life throughout all stages of their disease. While advances have been made in our understanding of the mechanisms of cancer pain, as well as how and when we treat metastatic pain, alleviating the pain of bone disease continues to present demanding clinical challenges. Several options are available to effectively control pain resulting from focal, multifocal, or generalized metastatic bone cancer. These options include nonpharmacologic, psychotherapeutic, and interventional management approaches. Overall, treatment is best approached in a multidisciplinary setting that allows patients to not only benefit from pain relief but also maintain their quality of life.

With expanded knowledge of the neurophysiology and related pharmacology of cancer bone pain, we can continue refining the clinical approach to alleviate pain and suffering in these patients.


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