Protein Tyrosine Phosphatase Meg2 Dephosphorylates Signal Transducer and Activator of Transcription 3 and Suppresses Tumor Growth in Breast Cancer

Fuqin Su; Fangli Ren; Yu Rong; Yangmeng Wang; Yongtao Geng; Yinyin Wang; Mengyao Feng; Yanfang Ju; Yi Li; Zhizhuang J Zhao; Kun Meng; Zhijie Chang

Disclosures

Breast Cancer Res. 2012;14(2):R38 

In This Article

Conclusion

In summery, we demonstrated that the cytoplasmic phosphatase PTPMeg2 directly mediates the dephosphorylation of pSTAT3 and negatively regulates STAT3 activity. Down regulated expression of PTPMeg2 is correlated with elevated phosphorylated STAT3 in human breast cancer tissues. Recovery of PTPMeg2 by adenovirus/retrovirus results in tumor regression in nude mouse models.

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