Hyaluronic Acid for Treatment of Osteoarthritis of the Knee

Repeated Injections and Progression to Knee Replacement

Judith Walsh, MD, MPH



In This Article


Intra-articular HA is in widespread use for knee osteoarthritis. A single course of treatment is a well established treatment option for knee OA, but the impact of repeated injections of intra-articular HA on clinical symptoms, progression to knee replacement and progression of disease has been less clear. Although one very well done randomized trial showed that patients who received four courses of intra-articular HA over a two and a half year period had an improvement in clinical symptoms, other important questions such as how this would compare with a single course of HA or the impact of other treatment schedules remains unknown.


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