Fatigue in Systemic Lupus Erythematosus

Grace E Ahn; Rosalind Ramsey-Goldman


Int J Clin Rheumatol. 2012;7(2):217-227. 

In This Article

SLE & Fatigue

Although there is no clear consensus on a definition for fatigue, Piper has defined fatigue as "an uncommon, abnormal or extreme whole bodily tiredness disproportionate or unrelated to activity or exertion".[11] Studies have shown that 53–80% of SLE patients have identified fatigue as one of their primary symptoms.[11] When fatigue severity was rated, the scores were similar to previous observations in patients with other chronic illnesses, such as Lyme disease and multiple sclerosis, and higher than the general population.[12,13] One of the major causes of morbidity in SLE patients is chronic, debilitating fatigue,[14] decreasing quality of life,[15–17] increasing risk of work disability[18] with associated cumbersome healthcare costs.[19]


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