Lifestyle and Metabolic Approaches to Maximizing Erectile and Vascular Health

D R Meldrum; J C Gambone; M A Morris; K Esposito; D Giugliano; L J Ignarro


Int J Impot Res. 2012;24(2):61-68. 

In This Article

Reduction of Inflammation Improves Endothelial Function and ED

More direct proof of a link between inflammation and ED is provided by experimentally producing and removing inflammation with concomitant assessment of endothelial and erectile function. When periodontal inflammation, which has been linked to cardiovascular disease, was aggressively treated, acute elevations of inflammatory markers were associated with a decrease of FMD. As the inflammation resolved over time, inflammatory markers regressed and FMD significantly increased.[72] When periodontal inflammation was created in an animal model, inflammatory markers increased and intracavernosal pressure, NOS activity and cyclic GMP all significantly decreased.[73] Minimizing infection and inflammation throughout the body, including avoiding fat accumulation, should improve both vascular and erectile health.