Neuroprotective Strategies for Hypoxic Ischemic Encephalopathy

Leslie Parker, PhD, NNP-BC; Carole Kenner, DNS, RNC-NIC, FAAN


NAINR. 2012;12(1):8-11. 

In This Article

Stem Cells

Stem cells have the ability to differentiate into a variety of cell types in the central nervous system.[31] Stem cell transplantation may minimize the effect of HIE by replacing damaged cells, promoting cell regeneration, inhibiting inflammation, and releasing trophic factors that heal and improve cell survival.[32,33] After intraventricular implantation in neonatal animal models with HIE, stem cells migrated to the area of injury in the brain.[32,33] Efficacy of stem cell transplantation, however, appears dependent on timing of implantation, and this therapeutic window is presently unknown. So, although stem cell therapy for HIE appears promising, a significant amount of research is required before it can be considered for use in neonates.


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