Neuroprotective Strategies for Hypoxic Ischemic Encephalopathy

Leslie Parker, PhD, NNP-BC; Carole Kenner, DNS, RNC-NIC, FAAN

Disclosures

NAINR. 2012;12(1):8-11. 

In This Article

Stem Cells

Stem cells have the ability to differentiate into a variety of cell types in the central nervous system.[31] Stem cell transplantation may minimize the effect of HIE by replacing damaged cells, promoting cell regeneration, inhibiting inflammation, and releasing trophic factors that heal and improve cell survival.[32,33] After intraventricular implantation in neonatal animal models with HIE, stem cells migrated to the area of injury in the brain.[32,33] Efficacy of stem cell transplantation, however, appears dependent on timing of implantation, and this therapeutic window is presently unknown. So, although stem cell therapy for HIE appears promising, a significant amount of research is required before it can be considered for use in neonates.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....