Responsiveness of a Patient in a Persistent Vegetative State After a Coma to Weekly Injections of Autologous Activated Immune Cells

A Case Report

Barbara Fellerhoff; Barbara Laumbacher; Rudolf Wank

Disclosures

J Med Case Reports. 2012;6(6) 

In This Article

Abstract and Introduction

Abstract

Introduction An 82-year-old Caucasian woman had remained in a persistent vegetative state after a coma of seven months duration, which occurred after a stroke with hemiplegia, nine years previously. The persistent vegetative state could be reversed in part by weekly injections with activated immune cells. After therapy, our patient responded to commands in addition to regaining spontaneous movements of both arms and the ability to swallow. This is the first report on the treatment with activated immune cells of a patient in a persistent vegetative state after a coma.
Case presentation An 82-year-old Caucasian woman presented with a persistent vegetative state subsequent to a coma. She retained respiratory and autonomic functions. As contact was not possible, physiotherapy was passive. Her skin was yellowish, and our patient did not move by herself. Vomiting repeatedly resulted from tube feeding. After a once-weekly treatment with activated immune cells sampled from our patient's blood and activated in vitro, several of her functions gradually returned. Our patient opened her eyes in the requested direction and turned her head toward people entering the room. She 'supported' nursing efforts, as the nurse noted a loss of spastic motions. The strength in both her arms returned, and she spontaneously moved her arm on the side experiencing hemiplegia. After three months, our patient could stick out her tongue upon demand. Finally, the swallow reflexes of our patient started to return. However, tube feeding was continued, and our patient died after aspiration of vomit following a feeding.
Conclusion The success of treatment with autologous activated immune cells in this patient may have resulted from the production of neuroactive substances, such as neurotrophin-3 and brain-derived neurotrophic factor, by activated immune cells. The deterioration of our patient could be reversed, as demonstrated by the restoration of motor strength in her hemiplegic side. In addition, our patient was able to induce motor responses upon request. It seems reasonable to conclude that activated immune cells may improve the chronic vegetative state in some patients.

Introduction

At the Institute of Immunology of the University of Munich, we have successfully treated several patients with psychiatric diseases with autologous activated immune cells (ACT). The treatment concept was based on previous observations of patients with persistent infections with Chlamydophila and the observed ability of immune cells to produce neuroactive substances.[1–3] The son of the patient in our case report had witnessed the tantrum of an autistic child and the subsequent dramatic improvements of the child after receiving activated immune cells.[2] He asked us whether we could help his mother. We agreed that we could and he discussed this with other family members. They encouraged him to proceed with treating his mother with activated immune cells.

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