Mosquirix (RTS,S)

A Novel Vaccine for the Prevention of Plasmodium falciparum Malaria

Kyle J Wilby BSP ACPR, PharmD; Tim TY Lau PharmD ACPR FCSHP; Samuel E Gilchrist MSc (Pharm), PhD; Mary HH Ensom PharmD FASHP FCCP FCSHP FCAHS

Disclosures

The Annals of Pharmacotherapy. 2012;46(3):384-393. 

In This Article

Abstract and Introduction

Abstract

Objective: To summarize and evaluate the literature for Mosquirix (RTS,S) and provide insight into the therapeutic and economic controversies of this novel malaria vaccine candidate.
Data Sources: A systematic literature search was performed using the terms Mosquirix; RTS,S; malaria; vaccine; and Plasmodium in MEDLINE (1948-November 2011), EMBASE (1980-November 2011), International Pharmaceutical Abstracts (1970-November 2011), Google, and Google Scholar.
Study Selection and Data Extraction: Clinical trials describing vaccine development, pharmacology, pharmacokinetics, efficacy, and safety were reviewed. For efficacy, clinical trials were reviewed that reported acquisition of malarial disease. Information regarding study design, population, study period, baseline characteristics, clinical outcomes, results, and assessors of quality was extracted.
Data Synthesis: Five randomized controlled trials and 4 follow-up extension studies were identified. In Phase 2 trials, vaccine efficacy rates were 33–65% in infants and 30–53% in children for preventing the first episode of clinical disease. In Phase 3 trials, vaccine efficacy was 56% in children aged 5–17 months. RTS,S reduced the number of clinical malaria episodes and prevented severe malaria in several studies. The follow-up period for vaccine efficacy ranged from 6 to 45 months. RTS,S 25 μg is administered intramuscularly as 3 injections given 1 month apart for infants and children. RTS,S appears to be generally well tolerated. A few cases of meningitis and seizures (within 7 days of vaccination) have been reported.
Conclusions: RTS,S has demonstrated efficacy and safety in Phase 1, 2, and 3 trials, and has the potential to decrease morbidity and mortality from malaria worldwide. Major challenges include determination of the duration of immunity, assessment of its cost-effectiveness, its use in special populations, and its dissemination in endemic regions. Pending further studies, RTS,S has the potential to become the benchmark as the first effective vaccine against malaria.

Introduction

Malaria is one of the most significant infectious disease burdens worldwide. The World Health Organization (WHO) reported 247 million cases of malaria in 2008, resulting in approximately 1 million deaths.[1] The disease especially targets the most vulnerable groups, namely infants and children, and accounts for approximately 20% of childhood deaths in Africa. Many people living in countries where malaria is endemic are unable to afford, or do not have access to, medications needed for treatment, which contributes to high morbidity and mortality. Furthermore, malaria has a devastating economic impact, with gross domestic products decreasing up to 1.3% in highly affected countries.

The 4 most common causes of malaria in humans are Plasmodium falciparum, P. vivax, P. malaria, and P. ovale. P. falciparum is the most fatal and represents the most common infection in Africa.[2] The P. falciparum life cycle consists of 2 stages: asymptomatic hepatic (pre-erythrocytic), followed by symptomatic blood (erythrocytic) stage[3] (Figure 1). During the erythrocytic phase, patients commonly present with fever, chills, weakness, headache, nausea, vomiting, and diarrhea. While erythrocyte stages are most responsible for these observable clinical symptoms, damage to hepatocytes and hepatomegaly may occur due to hepatic invasion during pre-erythrocyte phases.[4] A model vaccine would aim to target the parasite prior to development of hepatocellular damage.

Figure 1.

The lifecycle of Plasmodium falciparum in the human host. (1) Sporozoites are introduced from an infected Anopheles mosquito, while taking a blood meal; (2) sporozoites migrate to the hepatic circulation and infiltrate neighboring hepatocytes; (3) sporozoites undergo development and differentiation in the hepatocytes, producing thousand of merozoites; (4) merozoites are liberated from the hepatocyte in small cellular vesicles called merosomes, which disintegrate in the systemic circulation releasing the merozoites; (5) merozoites invade erythrocytes and continue maturation and division to become schizonts; the red blood cell ruptures resulting in the systemic release of more merozoites, that infect more erythrocytes; (6) some merozoites differentiate into male and female gametocytes; (7) gametocytes are then consumed by uninfected female Anopheles mosquito during a blood meal; cycle is then repeated.

Development of malaria vaccines to prevent infection has been an area of intensive research. Studies assessing potential targets and immune responses escalated throughout the 1980s and 1990s. Unfortunately, complexity of infection and variability in immunogenicity have limited the utility of potentially effective candidate vaccines.[5] However, recent advancements in antigen and adjuvant development have overcome many of these initial barriers and resulted in development of an innovative vaccine candidate.

Mosquirix (RTS,S) is a vaccine developed by Glaxo-SmithKline Inc. (GSK) in partnership with the PATH Malaria Vaccine Initiative as a preventive measure against P. falciparum clinical disease for infants and children living in endemic regions. It is the first malaria vaccine to reach Phase 3 trials and is currently being studied in ongoing clinical trials in Africa.[6] Results from these studies will provide regulatory bodies with data necessary to make decisions on preventive strategies and management. However, many controversies need to be addressed before the vaccine can be distributed and administered to patients in endemic areas. The objective of this review is to summarize and evaluate the literature pertaining to RTS,S and provide insight into therapeutic and economic controversies of this novel vaccine.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....