In the past, several studies have studied the association of malignancy and scleroderma with sometimes conflicting findings.[36•]
In a recent Danish study from a national registry in the period 1997–2006, Olesen et al. found 222 cases of cancer identified after the diagnosis of SSc. These authors reported an increased standardized incidence ratio for cancer of 1.5. Men had a higher incidence of cancer than women with a standardized incidence ratio of 2.2 (95% CI 1.7–2.8) for men and 1.3 (95% CI 1.1–1.6) for women. The most frequent malignancies reported were smoking-related and alcohol-related cancers.
Another cohort study in southwest England by Siau et al. [36•] studied malignancy in SSc patients and age-matched controls based on a regional healthcare database. They identified 15 malignancies out of 68 SSc patients. Although the total number of SSc cases was low, the authors calculated a relative risk of 3.15 (95% CI 1.77–5.20) in overall cancers and found the highest to be hematologic malignancies.
Curr Opin Rheumatol. 2012;24(2):165-170. © 2012 Lippincott Williams & Wilkins