Use of Raltegravir in Pediatric HIV-1 Infection

Marcia L. Buck, Pharm.D., FCCP, FPPAG; Kristi N. Hofer, Pharm.D; Michelle W. McCarthy, Pharm.D.; FASHP Susan B. Cogut, Pharm.D

Disclosures

Pediatr Pharm. 2012;18(1) 

In This Article

Abstract and Introduction

Introduction

Treatment options for pediatric patients with HIV-1 infection continue to expand. According to the updated Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection published in August 2011, 17 antiretroviral drugs have a pediatric indication from the Food and Drug Administration (FDA).[1] On December 21, 2011, this number grew again as the FDA extended the approval of raltegravir to include children and adolescents from 2 to 18 years of age.[2,3] Raltegravir was originally approved in 2007 for use in combination with other antiretroviral agents in adults with HIV-1 infection. It is currently the only HIV-1 integrase strand transfer inhibitor (INSTI) available in the United States and offers a safe and effective option for initial therapy for HIV-1 infection or treatment of patients with multidrug-resistant viral mutations.[4,5]

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