Review of Biologics in Children With Rheumatic Diseases

Shabina Habibi; Athimalaipet V Ramanan


Int J Clin Rheumatol. 2012;7(1):81-93. 

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Canakinumab is a human IL-1β antibody that binds to IL-1β, blocking its activity. It has a long plasma half-life and is administered at a dose of 4 mg/kg subcutaneously once a month. In a Phase II dose-escalation trial, 23 children were treated with canakinumab, in doses ranging from 0.5 to 9 mg/kg.[41] Seventeen of them had been previously treated with anakinra. A total of 59% of the children reached ACR-Pedi 50 response within 15 days, and 18% achieved inactive disease. Six out of 11 nonresponders to anakinra, responded to a single dose of canakinumab. A randomized, placebo-controlled double-blind study of monthly subcutaneous injection of canakinumab is currently underway.[103]


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