New Antivirals Show Promise for an Interferon-free Hepatitis C Treatment

Atif Zaman, MD, MPH

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These findings provide early evidence that the next generation of DAAs is more potent than the current generation in treating HCV genotype 1 infection. In this cohort of the most difficult-to-treat HCV patients — previous null responders with genotype 1 infection — a 24-week SVR of 90% was achieved after 24 weeks of quadruple therapy (2 DAAs and PEG/RBV). Even an interferon-free regimen of the 2 DAAs resulted in an SVR of 36%. Results are eagerly anticipated from the phase III trial currently under way.

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