The Emerging Phenomenon of Electronic Cigarettes

Pasquale Caponnetto; Davide Campagna; Gabriella Papale; Cristina Russo; Riccardo Polosa


Expert Rev Resp Med. 2012;6(1):63-74. 

In This Article

Five-year View

Electronic cigarettes can substantially decrease cigarette consumption without causing significant side effects, but large and carefully conducted controlled trials will be required before a definite answer about the efficacy and safety of these devices can be formulated. Some of these trials are now in progress in Italy[209,210] and New Zealand[211] and we anticipate that many more will follow in the coming years. This new research will also have to address long-term safety (including in patients with chronic respiratory diseases), role of nicotine dose titration and flavors/additives in guarding against relapse, reduction in the prevalence of tobacco-related diseases and efficacy in challenging subgroups of smokers (e.g., psychiatric patients and young adults). Moreover, research in the area of passive 'vaping' would be important for legislators. Hopefully, this research will form the basis for firm regulatory decisions. Moreover, in the future, liquid in these products shall be manufactured under sanitary conditions, using pharmaceutical grade nicotine.


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