Rescue Therapy for Acute Migraine, Part 1

Triptans, Dihydroergotamine, and Magnesium

Nancy E. Kelley, MD, PhD; Deborah E. Tepper, MD


Headache. 2012;52(1):114-128. 

In This Article

Common Inclusion and Exclusion Criteria

Most studies included patients with moderate to severe head pain at baseline. A few studies also included patients with mild head pain; when this was the case, these patients were a small proportion of the total number randomized. Many studies, but not all, limited participation to patients who met ICHD criteria for migraine with aura or migraine without aura. Some studies based inclusion on the participant's self-report of a prior diagnosis, while others utilized ED physicians or neurologists to diagnose the patients in the ED after informed consent was obtained but prior to randomization.

Typical exclusion criteria included: (1) age <18 or >60/65 (although some studies included patients up to age 70); (2) no well-established history of migraine; (3) recent trauma; (4) suspected secondary headache (thunderclap headache, fever, meningismus, altered mental status, focal neurological symptoms); (5) pregnancy; (6) contra-indication to study drug(s); or (7) use of study drug(s) (or drug from same class) within the previous 24–48 hours.


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