ERβ plays an essential role in ovarian function; changes in expression or activation of ERβ may have clinical consequences that take the form of infertility or cancer. Future studies need to elucidate the structure of the physiologically active dimer, identify genes specifically regulated by ERβ in the ovary, and address the role of coactivators and corepressors in ERβ signaling.
This work was supported by grants-in-aid from the Cancer Council of Victoria, the National Australia Bank Ovarian Cancer Research Foundation, the Granulosa Cell Tumor of the Ovary Foundation, and the National Health and Medical Research Council of Australia through a Senior Principal Research Fellowship to Peter J. Fuller. Prince Henry's Institute is supported by the Victorian Government's Operational Infrastructure Support program.
Semin Reprod Med. 2012;30(1):32-38. © 2012 Thieme Medical Publishers