Practical Considerations for Optimal Transdermal Drug Delivery

Cheryl Durand; Abdullah Alhammad; Kristine C. Willett


Am J Health Syst Pharm. 2012;69(2):116-124. 

In This Article

Other Considerations

Some manufacturers recommend that patients wearing patches avoid external heat sources (e.g., heating pads, electric blankets, heat lamps, saunas, hot tubs, sunlight), as heat may promote drug absorption through the skin. Drug-specific recommendations on the avoidance of heat are noted in the appendix.

Caregivers and patients should be sure to remove an old TDDS before applying a new one, as many patches have residual drug content even after the recommended application time. To decrease the risk of skin irritation, patients and caregivers should be instructed to rotate application sites; to avoid inadvertent eye contact, they should be reminded to wash their hands thoroughly after the application of a TDDS.

Finally, clinicians should emphasize to patients and caregivers the importance of discarding used patches according to the manufacturer instructions and out of the reach of children.


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