Practical Considerations for Optimal Transdermal Drug Delivery

Cheryl Durand; Abdullah Alhammad; Kristine C. Willett


Am J Health Syst Pharm. 2012;69(2):116-124. 

In This Article

Handling Adhesion Failures

The adhesive stability of medication patches is an important factor in product safety and effectiveness.[8] Many instances of TDDS adhesion failure have been reported to FDA's Drug Quality Reporting System,[54] including failures due to showering, swimming, or sweating. Other reported problems include poor adherence of a new patch, premature loss of a patch's adhesive properties, and "tenting up" of the adhesive edges of a patch. The failure of a patch to adequately adhere to the skin may lead to decreased medication absorption and, potentially, decreased clinical effects. There have also been reports of patch ingestion and medication overdoses in children who found patches that had fallen off a patient's body or were discarded improperly.[55,56] In addition to safety and efficacy concerns, if adhesive stability is not adequate, a patch may need to be replaced, increasing the financial cost to the patient.[8]

Ideally, adhesives should be non-irritating and nonsensitizing to the skin, adherent to different skin types and for the entire treatment period, comfortable to wear, removable without causing pain, and leave no residue on the skin when removed.[6,8] Most TDDS product packages contain instructions on the proper way to handle partial or complete detachment of the patch. Some manufacturers recommend the use of medical tape to reattach the patch, while others recommend the application of a new patch to a different site.


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