Cardiac Uses of Phosphodiesterase-5 Inhibitors

Bryan G. Schwartz, MD; Laurence A. Levine, MD; Gary Comstock, MD; Vera J. Stecher, PhD; Robert A. Kloner, MD, PhD

Disclosures

J Am Coll Cardiol. 2012;59(1):9-15. 

In This Article

Other Cardiovascular Uses

The PDE5Is are hypothesized to benefit but have not been tested in preeclampsia[51] and in patients undergoing cardiac surgery.[52] Sildenafil[53] and vardenafil[54] were each studied in a mouse model of unilateral hindlimb ischemia mimicking peripheral arterial disease. In each study, the PDE5I enhanced ischemia-induced angiogenesis as measured by vascular perfusion, tissue blood flow and vascular density.[53,54]

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