Salim Abdool Karim's Game Changers in HIV Prevention 2011

Salim S. Abdool Karim, MBChB, PhD


November 23, 2011

In This Article

Game Changers in the Field of HIV Prevention

The articles selected for this review contain important observations that are "game changers," defined as scientific observations that are likely to have substantial impact on the field of HIV prevention. In many instances, the article selected is one of several that contributes to the issue but is particularly important for its contribution to the totality of the issue.

In the last 18 months, a sea change has taken place in HIV prevention. A series of studies published since July 2010, presented here in chronological order, have generated a confluence of new evidence that has brought new hope that antiretrovirals can potentially change the course of the HIV epidemic when used as early treatment for prevention, as topical or oral preexposure prophylaxis (PrEP), or for the prevention of mother-to-child transmission (MTCT). Beyond antiretrovirals for HIV prevention, another game changer is the discovery of several broadly neutralizing antibodies that provide a new path for HIV vaccine development.


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