Topical and Systemic Therapies for Nickel Allergy

Antonella Tammaro; Alessandra Narcisi; Severino Persechino; Cristiano Caperchi; Anthony Gaspari


Dermatitis. 2011;22(05):251-255. 

In This Article

Narrowband Ultraviolet B

Phototherapy is very effective in the treatment of hand eczema; narrowband ultraviolet B (UVB) therapy has demonstrated clinical efficacy also in therapy for psoriasis and atopic dermatitis.[5]

The safety and efficacy of this therapy in cases of hand eczema was evaluated in a randomized controlled prospective study of 15 patients who had no response to conventional topical therapy. The patients were treated three times weekly for 9 weeks with narrowband UVB on one hand and with topical photochemotherapy using 0.1% 8-methoxypsoralen gel on the other hand. Patients were assessed once each week during the treatment period and were evaluated 10 weeks after the last treatment. All of the 12 subjects who completed the trial improved, showing a statistical difference between modalities. Both broadband and narrowband UVB appear to be as effective as topical psoralen plus ultraviolet A (PUVA) therapy in the treatment of chronic hand dermatitis. However, the risks of phototoxicity and dyspigmentation associated with local PUVA therapy make UVB therapy a preferable initial therapeutic option.[5]


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