Game Changers in Gastroenterology: 2011

David A. Johnson, MD


November 23, 2011

In This Article

Long-term Risk of Colorectal Cancer After Negative Colonoscopy

Brenner H, Chang-Claude J, Seiler CM, Hoffmeister M.
J Clin Oncol. 2011;29:3761-3767.

These German investigators have previously reported a case-control study showing that colonoscopy protects against colorectal cancer (CRC) for ≥ 10 years.[1] This was a larger study involving 1692 patients with CRC and 1896 population control patients. After a single negative colonoscopy, the age- and sex-adjusted odds ratios for CRC at the following intervals were 0.14 (1-2 years), 0.10 (3-4 years), 0.26 (5-9 years), 0.36 (10-19 years), and 0.41 (≥ 20 years). Risk reductions were seen for both right-sided and left-sided cancers.

Why Is This a Game Changer?

This investigation (conducted by gastroenterologists) shows that a negative colonoscopy is associated with substantial and extended risk reductions for both right- and left-sided colon cancers. The key issue is a quality exam!


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.