Patterns and Predictors of Sexual Activity Among Women in the Hormone Therapy Trials of the Women's Health Initiative

Gass, Margery L.S. MD, NCMP; Cochrane, Barbara B. PhD, RN; Larson, Joseph C. MS; Manson, JoAnn E. MD, DrPH, NCMP; Barnabei, Vanessa M. MD, PhD, NCMP; Brzyski, Robert G. MD, PhD; Lane, Dorothy S. MD, MPH; LaValleur, June MD; Ockene, Judith K. PhD, MEd, MA; Mouton, Charles P. MD, MS; Barad, David H. MD, MS


Menopause. 2011;18(11):1160-1171. 

In This Article


A majority of women with a partner in the WHI HT trials were satisfied with their sexual activity and frequency. Among all women, partnered or not, who were dissatisfied with their sexual activity, most would have preferred more sexual activity rather than less, especially women in the younger age groups. The strongest predictor of sexual activity at year 1 was sexual activity at baseline. The loss of a partner, partner illness, and poor self-rated health were important factors associated with the cessation of sexual activity in previously active women. Vulvovaginal atrophy, pelvic organ prolapse, and urinary incontinence were not significantly associated with cessation of sexual activity among those already sexually active. HT was associated with a higher rate of sexual activity at year 6 when limited to the subgroup of HT-adherent women, but there was no statistically significant difference in the intent-to-treat group. These findings further characterize the participants in the Women's Health Initiative and illustrate the complexity of factors related to the prevalence of sexual activity and satisfaction.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: