The Diagnosis and Management of Lymphocytic Hypophysitis

Sherry L Iuliano; Edward R Laws


Expert Rev Endocrinol Metab. 2011;6(6):777-783. 

In This Article


The case illustrations demonstrate a wide spectrum of presentation, imaging results and treatment strategies. Debate will continue as to whether lymphocytic hypophysitis is in fact a type of autoimmune phenomenon. Although the inflammatory process is relatively well stereotyped, there are many variations in the extent and character of the pathologic process. Not surprisingly, there is also variation in the response to therapy, in particular to corticosteroids. Those patients who have partial responses and relapses continue to represent therapeutic challenges. Longitudinal follow-up and diligent anterior and posterior pituitary replacement therapy are essential for successful management of lymphocytic hypophysitis. Routine pituitary laboratory studies and periodic repeat MRI scans should be part of the long-term plan.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: