Which Antiepileptic Drugs Work Best?

Andrew N. Wilner, MD


October 17, 2011

In This Article


Choosing an AED for a patient with epilepsy is a complex decision that must be individualized for each patient based on numerous factors including seizure type, epilepsy syndrome, comorbidities, and many other variables. An increasing number of head-to-head trials, although imperfect, offer guidance for the practitioner. The most recent study comparing pregabalin and lamotrigine in patients with newly diagnosed partial seizures suggests that while both AEDs have similar tolerability, lamotrigine provides better seizure control.


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