Treating Obstructive Sleep Apnea With Hypoglossal Nerve Stimulation

Arie Oliven

Disclosures

Curr Opin Pulm Med. 2011;17(6):419-424. 

In This Article

Prospective Developments and Future Research

Although the results of phase I and II studies are encouraging, they also suggest that hypoglossus nerve stimulation usually produces only a partial response. Consequently, this modality may be applicable to only certain OSA patients and appropriate selection criteria must be developed. Furthermore, modification of the electrodes to allow more complex stimulation algorithms is being pursued,[21,41••] and it remains to be seen whether this extension of the technique will improve targeted stimulation and mechanical efficacy. Although the effect of hypoglossus nerve stimulation during sleep appears to be primarily mediated through a mechanical process,[39] chronic stimulation may affect both control of genioglossus respiratory activity and histochemical and functional changes in the activated muscle fibers. The magnitude and clinical implications of these changes remain to be evaluated.

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