Obesity and Psoriasis
The association between psoriasis and obesity is the subject of a recent evidence-based review. A key question is whether obesity is causal[29–33] or a consequence of psoriasis.[30,34,35] It could be argued that a lack of physical activity, due either to the cosmetic impact of psoriasis or to the locomotor effect of psoriatic arthropathy, might predispose an individual to obesity. Childhood-onset obesity may particularly predispose to both psoriasis and psoriatic arthropathy, suggesting a genetic link. The association between psoriasis and obesity forms part of a wider association of psoriasis with a range of cardiovascular risk factors, namely atherosclerosis, diabetes mellitus and hypertension.[38–53] The separate association of psoriasis with smoking may be an important confounding variable, particularly with regard to hypertension and atherosclerosis.[52,53]
There is increasing evidence that progressive weight loss can produce significant improvements in the severity of psoriasis.[54–58] Perhaps the most direct evidence that obesity may be causal in psoriasis is the fact that bariatric sugery can produce rapid remission from psoriasis.[54,57,58] A confounding variable is the fact that the quality of life of the average patient undergoing bariatric surgery is significantly improved, which would reduce psychological stress and thus potentially the disease burden of psoriasis.
The British Journal of Dermatology. 2011;165(4):743-750. © 2011 Blackwell Publishing
Cite this: Obesity and the Skin - Medscape - Oct 01, 2011.