Associated Disorders of Chiari Type I Malformations

A Review

Marios Loukas, M.D., Ph.D.; Brian J. Shayota, B.S.; Kim Oelhafen, B.S.; Joseph H. Mill er, M.D.; Joshua J. Chern, M.D., Ph.D.; R. Shane Tubbs, M.S., P.A.-C., Ph.D.; W. Jerry Oakes, M.D.

Disclosures

Neurosurg Focus. 2011;31(3):e3 

In This Article

Bone Mineral Deficiency

In regard to bone mineral deficiencies, patients with familial vitamin D–resistant rickets have a higher incidence of CM-I,[5] believed to be due to overcrowding of the posterior fossa. In this condition, bone overgrowths and calvarial thickening as a result of low serum phosphate has been proposed to be the attributing factor. Further studies, however, have not found a difference in rachitic patients' posterior fossa volumes, and thus the pathophysiological mechanism remains unknown.[74] Kuether and Piatt[25] suggested in a case study that CM-I development from rickets is due to foramen magnum stenosis. Interestingly, Renier et al.[52] discovered that among 129 patients with oxycephaly, 15% suffered from rickets.

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