Reducing Mortality in Severe Sepsis and Septic Shock

Andrew T. Levinson, M.D., M.P.H.; Brian P. Casserly, M.D.; Mitchell M. Levy, M.D.


Semin Respir Crit Care Med. 2011;32(2):195-205. 

In This Article

Fluid Therapy

In the study by Rivers et al, patients in the protocolized care group received almost 1.5 L more total fluid in the first 6 hours than those in the standard therapy group, suggesting that aggressive early fluid resuscitation to correct hypovolemia may have a significant mortality benefit.[35] Some believe that the success of EGDT therapy is primarily due to the fact that patients receive early, aggressive restoration of fluid deficits.[43] With regard to the specific type of fluid, studies have shown no difference in mortality with the use of colloids or crystalloids.[44] A large, multicenter, double-blind trial found no difference in mortality between ICU patients randomized to albumin or normal saline.[45]


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.