Practical Diagnostic Approach to Uveitis

Anthony Grillo; Ralph D Levinson; Lynn K Gordon


Expert Rev Ophthalmol. 2011;6(4):449-459. 

In This Article

Five-year View

It is likely that significant changes in the diagnosis and management of uveitis syndromes will occur within the next 5 years. First, the advances in the sophistication of genetic testing will allow us to increasingly understand risk factors for development of uveitis and uveitis-associated disease complications, as well as susceptibility to immunomodulatory therapy. Second, new biomarkers of disease will allow a more precise diagnosis to be made using serologic analysis or using intraocular sampling for molecular diagnostics. These biomarkers will also be helpful in monitoring for disease response thus allowing more precise use of therapeutic interventions. Third, identification of potential pathogens in specific uveitis syndromes will increase through the use of sophisticated microbial genetic testing.[106] Fourth, a greater understanding of disease pathogenesis will allow for the development of disease-targeted therapies. These enhancements in diagnosis, therapeutic monitoring and disease-targeted therapies will yield improvements in patient care and protection from devastating vision loss from severe uveitis.


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