Systemic Sclerosis

An Update

Uwe-Frithjof Haustein, MD, PhD

Disclosures

Lab Med. 2011;42(9):562-572. 

In This Article

Microchimerism

In female SSc patients, the presence of fetal CD3-positive T cells in the maternal circulation[20] and of fetal cells in affected tissues[20] has been acknowledged by identifying Y-chromosome-specific DNA sequences by means of quantitative polymerase chain reaction (PCR) in statistically increased amounts as compared to healthy controls. The persistent microchimerism might cause SSc in certain patients by initiating a fetal anti-maternal graft vs host- (GvH-) like response.

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