Systemic Sclerosis

An Update

Uwe-Frithjof Haustein, MD, PhD


Lab Med. 2011;42(9):562-572. 

In This Article

Ultraviolet A

Ultraviolet A (UVA) irradiation (320–400 nm) penetrates into deeper layers of the skin. Repetitive UVA irradiation alone or in conjunction with photosensitizing agents (PUVA) increases the expression, synthesis, and activation of matrix metalloproteinases and additionally of cathepsins; it decreases the synthesis of collagen in dermal FBs; and destroys collagen cross links. On the other hand, UVA exerts cutaneous and systemic immunosuppressive effects, such as apoptosis of T cells and induction of IL-10. These effects may contribute to the improvement of skin score in SSc.[103]


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